MELISA is an optimised, clinically validated blood test which measures hypersensitivity to multiple metals from a single sample. MELISA can also to help in the diagnosis of active Lyme disease.
Exposure to metals in dental fillings and implants, joint prostheses, pacemakers, environmental pollutants and jewellery can lead to health problems in susceptible individuals.
MELISA improves laboratory diagnosis by confirming active disease in patients with clinical symptoms of Lyme.
The FDA has issued a statement addressing the concerns about the bio-compatibility and function of medical devices. Our conference in November 2018 mirrored these concerns
Download our leaflets on various topics such as metal hypersensitivity in orthopaedics, dentistry, spinal surgery and titanium implants.
In this study, 94% of patients confirmed significant health improvement after they followed recommendations based on the results of their MELISA test. Titanium and Other
The Experiences of Patients with Allergy to Metal Have you been diagnosed with metal hypersensitivity? We’ve been contacted by researchers at the University of Victoria,
Learn more about the effects of metals on health through these conferences: IAOMT Biological Dental & Medical Conference Hyatt Regency Sarasota March 11-13, 2021 iaomt.org/about-iaomt-conferences
On 23 November, a 3-hour session on Hypersensitization Reactions due to Metal and Metalloid Exposure will be broadcast as part of The 2nd International Industrial
The latest newsletter looks at actions taken by the FDA following on from the Medical Devices Committee meeting in November 2019. We also look at
People with known heightened sensitivity (allergy) to mercury or other components of dental amalgam should not get amalgam fillings, according to FDA’s new directives on
Metal Hypersensitivity in Knee Replacement Surgery Webinar recording Consultant Orthopaedic surgeons, Alberto Gregori and David Donaldson discuss the prevalence of hypersensitivity, symptoms post-op and how
The MELISA Summer Newsletter focuses on autoimmune diseases, inflammation and metal hypersensitivity. We cover an uplifting story of a nickel-allergic client who is now feeling
The latest Newsletter is out, the MELISA team are focusing on maintaining a healthy immune system and advice from functional medicine doctors. MELISA Spring Newsletter
The following conference is organised to with the aim to make the healthcare profession aware of the increase in diseases related to metal hypersensitivity and
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“In daily practice, I see how dental metal fillings (eg amalgam), as well as dental or orthopedic implants, can have an adverse effects on arrhythmias (eg atrial fibrillation). For many patients, establishing a timeline between a dental or orthopaedic procedure and their symptoms developing will aid diagnosis."
Cardiologist, University Hospital Brno, Czechia
“I have many patients that are interested in this type of testing associated with implants. Thank you for the great work you have done.”
Foot & Ankle Center, Wenatchee, WA, USA
“A type IV metal allergy is often overlooked as a culprit in many of today's chronic illnesses. MELISA testing gives targeted information on what needs to be avoided. Many patients get their life back with this information instead of remaining chronically ill for the rest of their days.”
Mount Diablo Integrated Wellness Center, Walnut Creek, CA, USA
“Working in holistic dentistry I use an integrated approach and treat the patient as a whole, focusing on the dental need in the larger context of the person’s overall well-being. MELISA provides me with invaluable information for the most suitable materials to be used.”
The Ella Clinic, London, UK
It took 16 years for this woman to find a doctor who considered metal hypersensitivity to surgical clips used in gallbladder surgery and was willing to remove them.
The patient described a myriad of symptoms including: abdominal pain, fatigue, forgetfulness, tremor in her hands, IBS symptoms, dry skin and hair. She was found to be allergic to nickel, cobalt and mercury and 8 metal clips were removed. Only 6 weeks after the removal of her cholecystectomy clips all her symptoms were alleviated and the constant pain was gone.
journals.lww.com/ijsgh/Fulltext/2021/01010/Surgical_clips_metal_allergy_postlaparoscopic.6.aspx
CDRH says that current evidence suggests some individuals may develop a heightened local or systemic immune or inflammatory reaction when exposed to certain metals contained in select implantable devices. They admit "that several significant scientific gaps exist in our understanding of host response to an implanted metal device" and that there is a need for tests to better predict or identify exaggerated immune responses in patients. CDRH welcomes the opportunity to interact and/or collaborate with investigators and researchers who are currently engaged in or considering research efforts related to host response to device implants. Those interested should email [email protected] using the title “Implant Research.”
CDRH’s Research on Biological Responses to Metal-Containing Devices
www.fda.gov
CDRH has initiated research efforts to address the knowledge gaps in understanding of a host response to an implanted metal device.In this study, published by the Institute of Dental Medicine at Charles University in Prague, 94% of patients confirmed significant health improvement after they followed treatment recommendations based on the result of their MELISA test. Many had experienced problems after orthopaedic surgery (inflammation, swelling, pain, itching, dermatitis, and loss of joint function); 25 patients had symptoms in the oral cavity (oral lichen planus, burning, itching, gingival hyperplasia, blisters, aphthous stomatitis, and dental implant rejection); one patient experienced chronic fatigue and tinnitus after endovascular coiling and 3 patients had various other health problems (chronic fatigue, headache and spine pain, atopic eczema, limb pain, and swelling).
www.hindawi.com/journals/bmri/2021/5512091/
Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study
www.hindawi.com
This study is aimed at proving the clinical benefit of the MELISA® test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements. A group of 305 patients aged 20-75 years with previously proven metal hypersensi...Migraines associated with nickel implant
This 35-year-old woman presented with a wide spectrum of symptoms including severe headaches, fatigue, sensitivity to light and noise, dizziness and tightness in her chest. She had previously had a patent foramen ovale closure device placed which was made from nitinol (45% titanium and 55% nickel). She was tested and found to be hypersensitive to nickel. The device was removed, and the patient’s headaches disappeared.
The surgeons stress that this is rare occurrence, but they advocate early removal of ASD/PFO devices and those patients with symptoms of nickel allergy and stress that possible symptoms of nickel allergy should be made clear to the patient prior to surgery.
Read more www.ncbi.nlm.nih.gov/pmc/articles/PMC8079502/
This case report describes eczema, pain and a burning sensation after a titanium implant was placed, after the implant was removed the symptoms disappeared. The authors go on to say that although titanium allergy is uncommon “Carrying out titanium allergy test should be routinely followed, especially in patients with known allergies to metals … Zirconium dioxide implants (ZrO2) or yttria-stabilized zirconia can serve as good substitutes as no allergic reactions have been reported yet from zirconium oxide”
www.hindawi.com/journals/crid/2021/5592934/
