Improving patient health through personalised testing

Symptom check

Metal sensitivity testing

Exposure to metals in dental fillings and implants, joint prostheses, pacemakers, environmental pollutants and jewellery can lead to health problems in susceptible individuals.

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Lyme disease testing

MELISA improves laboratory diagnosis by confirming active disease in patients with clinical symptoms of Lyme.

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FDA Statement and Metal Hypersensitivity

The FDA has issued a statement addressing the concerns about the bio-compatibility and function of medical devices. Our conference in November 2018 mirrored these concerns

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Download our leaflets on various topics such as metal hypersensitivity in orthopaedics, dentistry, spinal surgery and titanium implants.

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April 28, 2022

Addressing the Toxic Effects of the Exposome

Dentist Mary Ellen Chalmers will speak about “Identifying Oral Health and Dentistry Concerns in the Toxic Patient” at an online conference on functional medicine, 10-12

June 9, 2021

New MELISA research

In this study, 94% of patients confirmed significant health improvement after they followed recommendations based on the results of their MELISA test. Titanium and Other

March 23, 2021

Research study

The Experiences of Patients with Allergy to Metal Have you been diagnosed with metal hypersensitivity? We’ve been contacted by researchers at the University of Victoria,

February 17, 2021

Upcoming conferences

Learn more about the effects of metals on health through these conferences: IAOMT Biological Dental & Medical Conference Hyatt Regency Sarasota March 11-13, 2021

November 19, 2020

Webinar on metal sensitivity

On 23 November, a 3-hour session on Hypersensitization Reactions due to Metal and Metalloid Exposure will be broadcast as part of The 2nd International Industrial

November 19, 2020

MELISA Autumn Newsletter

The latest newsletter looks at actions taken by the FDA following on from the Medical Devices Committee meeting in November 2019. We also look at

September 25, 2020

FDA statement on amalgam

People with known heightened sensitivity (allergy) to mercury or other components of dental amalgam should not get amalgam fillings, according to FDA’s new directives on

August 26, 2020

Knee Hypersensitivity Webinar

Metal Hypersensitivity in Knee Replacement Surgery Webinar recording Consultant Orthopaedic surgeons, Alberto Gregori and David Donaldson discuss the prevalence of hypersensitivity, symptoms post-op and how

July 15, 2020

MELISA Summer Newsletter

The MELISA Summer Newsletter focuses on autoimmune diseases, inflammation and metal hypersensitivity. We cover an uplifting story of a nickel-allergic client who is now feeling

April 14, 2020

MELISA Spring Newsletter

The latest Newsletter is out, the MELISA team are focusing on maintaining a healthy immune system and advice from functional medicine doctors. MELISA Spring Newsletter

  • “In daily practice, I see how dental metal fillings (eg amalgam), as well as dental or orthopedic implants, can have an adverse effects on arrhythmias (eg atrial fibrillation). For many patients, establishing a timeline between a dental or orthopaedic procedure and their symptoms developing will aid diagnosis."

    MUDr. Jan Maňoušek

    Cardiologist, University Hospital Brno, Czechia

  • “I have many patients that are interested in this type of testing associated with implants. Thank you for the great work you have done.”

    Dr Scott Schroeder, Podiatric Physician and Surgeon

    Foot & Ankle Center, Wenatchee, WA, USA

  • “A type IV metal allergy is often overlooked as a culprit in many of today's chronic illnesses. MELISA testing gives targeted information on what needs to be avoided. Many patients get their life back with this information instead of remaining chronically ill for the rest of their days.”

    Dr Toril Jelter MD, General Practitioner & Pediatrician

    Mount Diablo Integrated Wellness Center, Walnut Creek, CA, USA

  • “Working in holistic dentistry I use an integrated approach and treat the patient as a whole, focusing on the dental need in the larger context of the person’s overall well-being. MELISA provides me with invaluable information for the most suitable materials to be used.”

    Dr Goran D. Stojanovic, Dental Surgeon

    The Ella Clinic, London, UK

4 weeks ago

Melisa Diagnostics

“I have repeatedly found myself minimized, marginalized and treated as a [second] class citizen whenever I inquired on the little known issue”. This is a quote from one patient interviewed by Dr. Dzifa Dordunoo, assistant professor at the University of Victoria, on the issues facing patients who develop hypersensitivity reactions after being implanted with metal-containing medical devices. Based on the answer given, Dr Dordunoo highlights the need to inform patients of the metal composition of the devices implanted and also include pre-op screening question about previous reactions to metals.
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3 months ago

Melisa Diagnostics

On International #womeninscience Day we remember Prof Vera Stejskal who is sadly no longer with us. We miss her unquenchable optimism, can-do attitude, thirst for knowledge and burning desire to bring about change so that people who are suffering from metal hypersensitivity get the support and treatment they need. Vera, we do our best to follow in your footsteps but your shoes are hard to fill.Dr Vera Stejskal, inventor of MELISA testing, has passed away after a brief period of illness. A pioneer in the field of immunotoxicology, her groundbreaking research into the connection between metal induced inflammation and chronic disease has helped hundreds of patients regain their health. She was born in Prague and fled to Sweden after the 1968 invasion of Czechoslovakia.

She started work at the Department of Immunology at the University of Stockholm where she became Associated Professor of Immunology in 1976. She then joined Astra, running its immunotoxicology division where one of her first assignments was to have a final look at a new drug that was being tested: omeprazole. Studies had showed necrotizing vasculitis in the small intestine of some dogs, and the project looked set to be terminated. The group she led was able to prove that the drug had no such side effects and the drug went on to become Losec, the best-selling drug in the world.

As a next project, Dr Stejskal was asked to develop a test for the diagnosis of drug allergy among workers in Astra’s pharmaceutical factories. They had noticed that some workers complained of allergy related symptoms while working in the factories – symptoms that would completely disappear during holidays. Dr Stejskal applied the lymphocyte transformation test, originally developed in the 1960s for evaluating histocompatible class II HLA antigens. She modified it for class II antigen typing and also applied it extensively to detecting type IV allergies to drugs. As of today, Astra is still using this blood test to ensure workers are not exposed to drugs that might be inducing sensitivities.

In 1990 a colleague of Dr Stejskal, dermatologist Dr Margit Forsbeck, asked to try the new test on patients who suspected their symptoms were caused by their dental metal fillings, mainly amalgam. At the time, the only option was patch testing – as a skin test not very reliable for testing metal allergy. Dr Stejskal compared lymphocyte reactions between patients and healthy controls and found to her surprise that patients’ lymphocytes reacted more frequently and strongly to mercury salts than controls’. The results were published in The Journal of Clinical Immunology in 1996 (Mercury-specific lymphocytes: An indication of mercury allergy in man).

In 1999, Astra and Zeneca group merged to form AstraZeneca. Since there were now three immunotoxicological departments, Dr Stejskal decided to leave the company and pursue the test on her own. Astra was a pharmaceutical rather than a diagnostic company, and had no interest in developing the test further. She patented it under the name MELISA, and acronym for Memory Lymphocyte Immuno Stimulation Assay.

She then devoted her life to the test, and was affiliated with the Karolinska Institute, Stockholm. From 2004 to 2012 she was an associated professor at the Department of Immunology and Microbiology, First Medical faculty at Charles University, Prague, Czech Republic, where she directed research on the pathological role of metals in chronic diseases.

Dr Stejskal and colleagues worked tirelessly to prove the validity of the MELISA, and that its test results were repeatable, reliable and useful. The test promised to open a new field of medicine, investigating the link between chronic disease and an allergy to an everyday metal exposure. The allergies were rare, but for those affected they could be debilitating – yet once their condition was diagnosed, the patient’s health could improve with removal or replacement of allergy causing metals. Dr Stejskal organised conferences to educate and facilitate cooperation between researchers, doctors and dentist, and dentistry especially was a key part of the treatment protocol. Many professional relationships turned into close friendships.

MELISA started to be performed under license by certified laboratories worldwide and university researchers were using the test in their work. In total, Dr Stejskal published more than 100 scientific articles and was frequently a speaker on the subject of immunotoxicity of heavy and transitional metals and the link to the development/aggravation of allergy and autoimmunity. She was also board member of European Academy of Environmental Medicine and scientific member of ESAAM and I-GAP.

Dr Stejskal never planned to retire – for her, her work was her passion in life. She believed rigorous scientific studies would bring a better, healthier world. The MELISA test is her medical legacy, and will now continue without her. She has left us to go on to further discoveries and adventures.
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