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  • ALERT: Do not send your samples for MELISA testing to the lab in Germany due to the closure of the lab. More information HERE.

Melisa testing

Improving patient health through personalised testing

MELISA is an optimised, clinically validated blood test which measures hypersensitivity to multiple metals from a single sample.

Latest news


A recently published review articles looks at the connection between metal hypersensitivity and implant failure, with a particular focus on titanium. There is now a considerable body of evidence showing that titanium can induce hypersensitivity. This review gives a useful overview of several case histories where symptoms started after placement of a titanium implants and disappeared after the removal.


The MELISA autumn newsletter is out and, among many other things, covers two new publications by Dr Dzifa Dordunoo and her team of researchers, who continue to expose the lack of knowledge surrounding metal hypersensitivity in the healthcare system.


On this new podcast, Shari Guess interviews patients, medical professionals and industry insiders and has important discussions regarding the all-to-commonly experienced, but lesser identified symptoms of hypersensitivity to metals contained in implanted medical and dental hardware.


A new, remarkable, review of metal allergy should once and for all put an end to the belief that metal allergy causes nothing more than skin reactions. It lists hundreds of publications describing metal-specific allergy responses, identifying over 50 unique manifestations. According to the authors: “metals constitute one of the major classes of allergens responsible for a disproportionately large segment of the total burden of disease associated with allergy.”

This new study determined the relevance of metal hypersensitivity in patients with failed orthopedic implants and those requiring orthopedic implant surgery, using MELISA testing. Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study Podzimek S. et al. Clin Immunol. 2022 Dec;245:109152. doi: 10.1016/j.clim.2022.109152.

New article lists hundreds of publications describing metal-specific hypersensitivity responses, identifying over 50 unique manifestations.

Journal of Toxicology and Environmental Health, Part B. Critical Reviews. Volume 25, 2022 - Issue 6


Dentist Mary Ellen Chalmers will speak about "Identifying Oral Health and Dentistry Concerns in the Toxic Patient" at an online conference on functional medicine, 10-12 June.

This online functional medicine conference uses a case-based, integrated approach to effectively deliver the tools necessary for clinicians to diagnose and treat the toxic component of their patients’ total health pictures.

More info here


In this study, 94% of patients confirmed significant health improvement after they followed recommendations based on the results of their MELISA test.

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study
Read the article here

The Experiences of Patients with Allergy to Metal Have you been diagnosed with metal hypersensitivity? We’ve been contacted by researchers at the University of Victoria, School of Nursing, Canada who are running a study called ‘The Lived Experiences of Metal Hypersensitivity.

Learn more about the effects of metals on health through these conferences:

On 23 November, a 3-hour session on Hypersensitization Reactions due to Metal and Metalloid Exposure will be broadcast as part of The 2nd International Industrial and Environmental Toxicology conference. The session runs 18.30-21 GMP+3. Programme below and here as well. Register here. Hypersensitization Reactions due to Metal and Metalloid Exposure
The latest newsletter looks at actions taken by the FDA following on from the Medical Devices Committee meeting in November 2019. We also look at systemic hypersensitivity in a spinal patient and nickel allergy in those with coeliac disease. Read it HERE
People with known heightened sensitivity (allergy) to mercury or other components of dental amalgam should not get amalgam fillings, according to FDA's new directives on amalgam fillings. Inhaling mercury vapour “may be harmful in certain patients” and “uncertainties remain on the effects that long-term exposure to dental amalgam may have on the specific high-risk groups”.
Metal Hypersensitivity in Knee Replacement Surgery Webinar recording Consultant Orthopaedic surgeons, Alberto Gregori and David Donaldson discuss the prevalence of hypersensitivity, symptoms post-op and how to identify susceptible patients pre-op. Julia Glendinning shows how MELISA can be used to screen pre-op and help identify those with metal hypersensitivity post-op. Mark Watson from B. Braun presents a coated hypoallergenic alternative.
The MELISA Summer Newsletter focuses on autoimmune diseases, inflammation and metal hypersensitivity. We cover an uplifting story of a nickel-allergic client who is now feeling great post-surgery. We look at nickel allergy in children and how legislation restricting exposure has reduced the risk of developing nickel allergy. READ NEWSLETTER

    “I have many patients that are interested in this type of testing associated with implants. Thank you for the great work you have done.”

    Dr Scott Schroeder, Podiatric Physician and Surgeon
    Foot & Ankle Center, Wenatchee, WA, USA

    “A type IV metal allergy is often overlooked as a culprit in many of today's chronic illnesses. MELISA testing gives targeted information on what needs to be avoided. Many patients get their life back with this information instead of remaining chronically ill for the rest of their days.”

    Dr Toril Jelter MD, General Practitioner & Pediatrician
    Mount Diablo Integrated Wellness Center, Walnut Creek, CA, USA

    “Working in holistic dentistry I use an integrated approach and treat the patient as a whole, focusing on the dental need in the larger context of the person’s overall well-being. MELISA provides me with invaluable information for the most suitable materials to be used.”

    Dr Goran D. Stojanovic, Dental Surgeon
    The Ella Clinic, London, UK

    “In daily practice, I see how dental metal fillings (eg amalgam), as well as dental or orthopedic implants, can have an adverse effects on arrhythmias (eg atrial fibrillation). For many patients, establishing a timeline between a dental or orthopaedic procedure and their symptoms developing will aid diagnosis."

    MUDr. Jan Maňoušek
    Cardiologist, University Hospital Brno, Czechia