R&E Diagnostics

The MELISA® test (MEmory Lymphocyte Immuno-Stimulation Assay) is a specialized blood test designed to detect Type IV (delayed-type) hypersensitivity reactions to metals. It works by measuring the immune system’s response to specific allergens through a refined version of the lymphocyte transformation test (LTT). 

For whom is the MELISA® test suitable:

MELISA® is primarily used for individuals in whom it is suspected that immune reactions to metals may be causing or worsening chronic health problems. These problems may include fatigue, fibromyalgia, depression, joint and muscle pain, dermatitis, burning mouth syndrome, or other unexplained inflammatory symptoms. The test is especially relevant for people with exposure to dental metals, orthopedic implants, surgical screws, pacemakers, or other metallic devices.
Standard allergy tests, such as skin patch testing, may fail to detect hypersensitivity to metals like titanium, which MELISA® can uncover.
Studies show that identifying and removing reactive metals based on MELISA® results can lead to substantial clinical improvement in many patients. The test is unique in its ability to differentiate immune hypersensitivity from mere toxic exposure, providing critical insights that can guide safer material choices in dentistry and surgery.
The test can also be used preoperatively to assess the risk of implant rejection or to screen individuals with occupational exposure to metals.

To order the test in Canada / in the US, please contact ... - possible to add "ORDER TESTING" button, or link to a separate page/contact page where orders could be made.  

A range of testing panels tailored to different sources of exposure is offered, including dental amalgam materials, non-noble and noble metals used in crowns and bridges, and orthopedic implant alloys. 

Note that MELISA® can be affected by certain medications and some health conditions. Patients are advised to avoid immunosuppressive medications, such as steroids, for at least three weeks before testing. These could suppress immune responses and produce false negative results, or testing could be non-evaluable. More information on medication and health can be found HERE.

Access to the MELISA® test requires a referral from a licensed healthcare provider. Once a test is ordered, the patient receives a test kit and has blood drawn. Samples should be shipped at room temperature and delivered in 24 hours, or at the most in 48 hours of blood draw. Phlebotomy can also be performed directly at our laboratory in London, Ontario.

More information about the MELISA® test can be found on the MELISA Diagnostic website.