Research projects

We are particularly interested in cooperation with studies involving allergy to orthopaedic devices and dental implants and would welcome approaches from researchers and clinicians alike. Please contact us at [email protected].

MELISA in current studies and projects:

Cardiology and metal hypersensitivity

Department of Internal Medicine and Cardiology, University Hospital Brno, Brno, Czech Republic

Delayed-type hypersensitivity to metals of environmental burden in patients with Takotsubo syndrome – Is there a clinical relevance?

Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices


Lung disease and sarcoidosis

Department of Environmental and Occupational Medicine, Sackler School of Medicine, Tel Aviv University

Identification of metal sensitization in sarcoid-like metal-exposed patients by the MELISA® lymphocyte proliferation test — a pilot study


Validation of Lyme disease testing

Validation of cellular tests for Lyme borreliosis (VICTORY) study. 150 patient and 225 healthy controls tested in four different cellular tests to determine sensitivity and specificity. More info here


Metal hypersensitivity in patients with failed orthopaedic implants

Institute of Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic. Data presented at International Conference on Metal Detoxification, Berlin, 10 June 2019


Management of Systemic Effects of Metal Implants and Galvanic Corrosion

Foot and Ankle Center Wenatchee. Data was presented by Dr Scott Schroeder at FDA Committee Meeting on immune responses to metals in medical devices on 13th November, 2019. See presentation here.