Research projects


MELISA conducts its own research into metal hypersensitivity and has most recently published articles on cardiac disease, fibrolmyalgia and connective tissue disease.
We maintain a library of articles and research on the effects of metal allergy and the diseases with which it may be associated.

We are particularly interested in cooperation with studies involving allergy to orthopaedic devices and dental implants and would welcome approaches from researchers and clinicians alike. Please contact us at [email protected].


MELISA in current studies and projects:


Cardiology and metal hypersensitivity

Department of Internal Medicine and Cardiology, University Hospital Brno, Brno, Czech Republic

Delayed-type hypersensitivity to metals of environmental burden in patients with Takotsubo syndrome – Is there a clinical relevance?

Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy


Lung disease and sarcoidosis

Department of Environmental and Occupational Medicine, Sackler School of Medicine, Tel Aviv University

Identification of metal sensitization in sarcoid-like metal-exposed patients by the MELISA® lymphocyte proliferation test — a pilot study


Validation of Lyme disease testing

Validation of cellular tests for Lyme borreliosis (VICTORY) study. 150 patient and 225 healthy controls tested in four different cellular tests to determine sensitivity and specificity. More info HERE


Metal hypersensitivity in patients with orthopaedic and dental implants

Institute of Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic. Data presented at International Conference on Metal Detoxification, Berlin, 10 June 2019

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA Test: Follow up Study


Management of Systemic Effects of Metal Implants and Galvanic Corrosion

Foot and Ankle Center Wenatchee. Data was presented by Dr Scott Schroeder at FDA Committee Meeting on immune responses to metals in medical devices on 13th November, 2019. See presentation HERE


Metals and Scoliosis

Rebecca Dutton is conducting research into the possible connection between metal exposure (particularly to mercury) and the the development of idiopathic scoliosis. More info HERE