MELISA is an optimised, clinically validated blood test which measures hypersensitivity to multiple metals from a single sample. MELISA can also to help in the diagnosis of active Lyme disease.
Exposure to metals in dental fillings and implants, joint prostheses, pacemakers, environmental pollutants and jewellery can lead to health problems in susceptible individuals.
MELISA improves laboratory diagnosis by confirming active disease in patients with clinical symptoms of Lyme.
The FDA has issued a statement addressing the concerns about the bio-compatibility and function of medical devices. Our conference in November 2018 mirrored these concerns
Download our leaflets on various topics such as metal hypersensitivity in orthopaedics, dentistry, spinal surgery and titanium implants.
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“In daily practice, I see how dental metal fillings (eg amalgam), as well as dental or orthopedic implants, can have an adverse effects on arrhythmias (eg atrial fibrillation). For many patients, establishing a timeline between a dental or orthopaedic procedure and their symptoms developing will aid diagnosis."
Cardiologist, University Hospital Brno, Czechia
“I have many patients that are interested in this type of testing associated with implants. Thank you for the great work you have done.”
Foot & Ankle Center, Wenatchee, WA, USA
“A type IV metal allergy is often overlooked as a culprit in many of today's chronic illnesses. MELISA testing gives targeted information on what needs to be avoided. Many patients get their life back with this information instead of remaining chronically ill for the rest of their days.”
Mount Diablo Integrated Wellness Center, Walnut Creek, CA, USA
“Working in holistic dentistry I use an integrated approach and treat the patient as a whole, focusing on the dental need in the larger context of the person’s overall well-being. MELISA provides me with invaluable information for the most suitable materials to be used.”
The Ella Clinic, London, UK
"A possible metal allergy could be considered when a patient presents with nonspecific, possibly life-threatening complications, as seen with the patient in this case report." Here is another case, when nickel from surgical clips contributed to various health problems. Only when MELISA diagnosed nickel allergy and the clips were removed was there a change in health status: the patient's neuropathy improved, she had no more rashes, her fatigue significantly improved, and more. The authors conclude that potential allergens should be investigated BEFORE procedures involving surgical clips. Hypoallergenic clips should also be offered to those with a known reactivity to metals.
The Improvement of Nonspecific Chronic Symptoms Post-Gallbladder Clip Removal
www.cureus.com
Laparoscopic cholecystectomy is the first line of treatment for patients with symptomatic gallstones. Surgical clips made of stainless steel are still used by surgeons during these laparoscopic proced...It can be difficult to pinpoint the cause of pain after implant surgery. In this case, it turned out to be a symptom of metal allergy, and only disappeared after implant removal. Eight years after the initial cervical implant surgery, a skin rash appeared on the sole of the patient’s foot. The rash didn’t improve with standard treatment and a patch test and LTT was performed to check for metal allergy. Metal allergy was diagnosed and the patient’s metal dentures were removed and replaced with ceramic ones. However, the skin rash did not improve until the cervical implant was removed, which also lead to disappearance of the chronic neck pain which had continued after the surgery.
Cervical Implant Allergy With Chronic Neck Pain: A Case Report
www.ncbi.nlm.nih.gov
A 57-year-old woman underwent cervical implant surgery for a dislocated cervical spine fracture, and she complained of continuous intractable neck pain after surgery. Eight years later, she developed ...This remarkable review of metal hypersensitivity should once and for all put an end to the belief that metals cause skin reactivity and nothing more; it lists hundreds of publications describing metal-specific hypersensitivity responses, identifying over 50 unique manifestations. It’s a real shame that the article is not open access since the content needs to be widely known.
A comprehensive summary of disease variants implicated in metal allergy
www.tandfonline.com
Allergic disease represents one of the most prominent global public health crises of the 21st century. Although many different substances are known to produce hypersensitivity responses, metals con...We are thrilled that the US FDA is finally doing more studies on the effect of metal implants, while also admitting that animal studies do not accurately reflect what happens when metallic implants are placed in humans. In this study, they look at the potential issues with the nickel titanium (NiTi) alloy, concluding that: "the results here demonstrated that nickel and NiTi NP can enter both types of cells, with deleterious consequences." and "there are significant biocompatibility issues in metallic implants that may be missed because humans respond to nickel ions and nano-/micro-sized NiTi particles much differently than rodents".
Examining the role of nickel and NiTi nanoparticles promoting inflammation and angiogenesis
www.tandfonline.com
Nickel titanium (NiTi, or Nitinol) alloy is used in several biomedical applications, including cardiac, peripheral vascular, and fallopian tube stents. There are significant biocompatibility issues...Did you know that titanium dioxide - one of the most popular pigments in use - is commonly added to food, as well as to toothpaste, sunscreen and cosmetics? This year, the use of titanium dioxide (E171) as a food additive in the European Union is prohibited due to potential genotoxicity, i.e. the titanium dioxide particles’ ability to damage DNA.
A class action lawsuit has now been filed against the Mars Corporation, maker of Skittles, due to the titanium content in the sweets. In 2016, the company announced they would be eliminating titanium from their products by 2021, but so far there has been no change.
www.forbes.com/sites/ninashapiro/2022/07/17/skittles-candy-maker-sued-due-to-presence-of-additive...
Skittles Candy Maker Sued Due To Presence Of Additive Deemed “Toxic”
www.forbes.com
Mars Corporation, makers of Skittles, are defendants in a class action lawsuit claiming that these candies contain harmful additives.