MELISA is an optimised, clinically validated blood test which measures hypersensitivity to multiple metals from a single sample. MELISA can also to help in the diagnosis of active Lyme disease.
Exposure to metals in dental fillings and implants, joint prostheses, pacemakers, environmental pollutants and jewellery can lead to health problems in susceptible individuals.
MELISA improves laboratory diagnosis by confirming active disease in patients with clinical symptoms of Lyme.
The FDA has issued a statement addressing the concerns about the bio-compatibility and function of medical devices. Our conference in November 2018 mirrored these concerns
Download our leaflets on various topics such as metal hypersensitivity in orthopaedics, dentistry, spinal surgery and titanium implants.
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“In daily practice, I see how dental metal fillings (eg amalgam), as well as dental or orthopedic implants, can have an adverse effects on arrhythmias (eg atrial fibrillation). For many patients, establishing a timeline between a dental or orthopaedic procedure and their symptoms developing will aid diagnosis."
Cardiologist, University Hospital Brno, Czechia
“I have many patients that are interested in this type of testing associated with implants. Thank you for the great work you have done.”
Foot & Ankle Center, Wenatchee, WA, USA
“A type IV metal allergy is often overlooked as a culprit in many of today's chronic illnesses. MELISA testing gives targeted information on what needs to be avoided. Many patients get their life back with this information instead of remaining chronically ill for the rest of their days.”
Mount Diablo Integrated Wellness Center, Walnut Creek, CA, USA
“Working in holistic dentistry I use an integrated approach and treat the patient as a whole, focusing on the dental need in the larger context of the person’s overall well-being. MELISA provides me with invaluable information for the most suitable materials to be used.”
The Ella Clinic, London, UK
We are thrilled that the US FDA is finally doing more studies on the effect of metal implants, while also admitting that animal studies do not accurately reflect what happens when metallic implants are placed in humans. In this study, they look at the potential issues with the nickel titanium (NiTi) alloy, concluding that: "the results here demonstrated that nickel and NiTi NP can enter both types of cells, with deleterious consequences." and "there are significant biocompatibility issues in metallic implants that may be missed because humans respond to nickel ions and nano-/micro-sized NiTi particles much differently than rodents".
Examining the role of nickel and NiTi nanoparticles promoting inflammation and angiogenesis
www.tandfonline.com
Nickel titanium (NiTi, or Nitinol) alloy is used in several biomedical applications, including cardiac, peripheral vascular, and fallopian tube stents. There are significant biocompatibility issues...Did you know that titanium dioxide - one of the most popular pigments in use - is commonly added to food, as well as to toothpaste, sunscreen and cosmetics? This year, the use of titanium dioxide (E171) as a food additive in the European Union is prohibited due to potential genotoxicity, i.e. the titanium dioxide particles’ ability to damage DNA.
A class action lawsuit has now been filed against the Mars Corporation, maker of Skittles, due to the titanium content in the sweets. In 2016, the company announced they would be eliminating titanium from their products by 2021, but so far there has been no change.
www.forbes.com/sites/ninashapiro/2022/07/17/skittles-candy-maker-sued-due-to-presence-of-additive...
Skittles Candy Maker Sued Due To Presence Of Additive Deemed “Toxic”
www.forbes.com
Mars Corporation, makers of Skittles, are defendants in a class action lawsuit claiming that these candies contain harmful additives.Can titanium clips used in surgery cause health issues? This is a case of a 55-year-old female who after a gallbladder removal experienced pain, diarrhea, nausea and neuralgia. The patient was eventually diagnosed with a hypersensitivity reaction to the titanium clips used in the surgery. Four clips were identified and removed and the symptoms improved after removal. The patient had a known history of metal (nickel) allergy, as well as multiple other allergies. The authors recommend preoperative allergy testing for patients with history of known allergies, especially those with metal allergies to prevent further complication or aid in diagnosis and treatment.
www.cureus.com/articles/94815-hypersensitivity-reaction-post-laparoscopic-cholecystectomy-due-to-...
Hypersensitivity Reaction Post Laparoscopic Cholecystectomy Due to Retained Titanium Clips
www.cureus.com
Titanium is an inert metal that has many medical uses and applications because of its biocompatibility. However, titanium is not completely devoid of adverse reactions. This was the case of a 55-year-...In this study, genes of patients who had developed allergies to their CoCr hip implants were compared to genes of patients who remained symptom-free. The results showed that development of delayed type hypersensitivity is associated with patient age, gender, level of metal exposure and the presence of certain genes (HLA class II alleles). The authors suggest that more resources should be directed towards improving the understanding of patients' immune responses to implant materials.
www.nature.com/articles/s43856-022-00137-0
www.nature.com
Langton et al. identify HLA alleles associated with development of delayed-type hypersensitivity following hip arthroplasty. They train an algorithm to predict hypersensitivity which could improve imp...If a patient has a known metal allergy, Dr. Pritchett recommends metal-free implant options. Also, if a patient is concerned about metal allergy or sensitivity, metal allergy tests can be done. He talks about his experience with patients with metal hypersensitivity, and what options patients have, on YouTube: www.youtube.com/watch?v=mrx9Pd8wVLo
www.seattlejointsurgeon.com/specialties/metal-free-joint-replacement
Metal Free Hip Replacement Dr. Pritchett
www.youtube.com
Metal Free Hip Replacement for Allergy to metal. Made with a Ceramic Coating for Adventure Sports and in Active Patients. Less invasive Surgery For A lifeti...