Improving outcomes in holistic dentistry

Do your patients suffer from?

Autoimmune disease, atopic conditions, chronic fatigue, fibromyalgia
Oral diseases: Lichen planus, stomatitis, glossodynia, burning mouth, cheilitis
Successive implant failure with no infection ie “cluster patients”

If so, you may consider MELISA testing as part of your diagnostic protocol

In some patients, metals can provoke an immune response, which may lead to diverse symptoms, “both local and systemic hypersensitivity reactions” are seen according to FDA. (1)

MELISA is a clinically validated, standardized and widely published blood test, which measures metal-induced type IV delayed hypersensitivity (2, 3) Based on the results, you can be sure that that you are using the most bio-compatible solution for each unique patient. (4, 5)

MELISA lets you screen susceptible patients before starting the dental work
Establish if dental metal hypersensitivity is contributing to chronic conditions

Published studies confirming the connection between chronic disease and metal hypersensitivity as diagnosed by MELISA testing:

76% of chronic fatigue patients experienced health improvement after removing dental
restorations containing allergenic metals, identified by MELISA testing. (6)
71% of patients with autoimmune diseases and mercury allergy improved after
having their amalgam fillings removed. (7)
50% of fibromyalgia patients showed that after restricting exposure to metals they were
allergic to, they no longer fulfilled the criteria for fibromyalgia. 20% had reduced trigger
points and all reported improvement in symptoms. (8)
37% of symptomatic patients (muscle and joint pain, chronic fatigue, dermatitis and
acne-like inflammation) were found to be allergic to their titanium dental work/implants
through MELISA testing (all negative in patch testing). Following removal of the implants,
all 54 patients showed remarkable clinical improvement. (9)
Based on more than 20 years’ research, MELISA has identified symptoms and indicators for
those likely to be metal hypersensitive. Studies show that if metal allergy is found, both
outcome and symptoms will improve if exposure to relevant metals is reduced. Both a
comprehensive questionnaire and a brief online version are available. A complete evaluation
with a list of metal exposure can be provided if the full questionnaire is completed.


1) FDA. Biological Responses to metal implants. 2019
2) Valentine-Thon E, et al. LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Neuro Endocrinol Lett 2006; 27(Suppl 1): 17-24
3) Müller K, Valentine-Thon E.Hypersensitivity to titanium: Clinical and laboratory evidence. Neuro Endocrinol Lett 2006; 27(Suppl 1): 31-35
4) Zielinski J, Lacy TA, Phillips JH. Carbon Coated Implants as a New Solution for Metal Allergy in Early-Onset Scoliosis: A Case Report and Review of the Literature. Spine Deformity 2(1):76-80 2014
5) Clague GA, McGann G, Gilbert H. An unusual allergy to platinum embolization coils. Cardiovasc Intervent Radiol. 2012
6) Stejskal V, et al. Metal-specific lymphocytes: biomarkers of sensitivity in man. Neuroendocrinology Letters. 1999, pp. 289-298.
7) Prochazkova J, et al. The beneficial effect of amalgam replacement on health in patients with autoimmunity. Neuroendocrinology Letters. 25 (3), 2004, pp. 211-218.
8) Stejskal V, Reynolds T, Bjørklund G. Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease. Journal of Trace Elements in Medicine and Biology. 31, 2015, pp. 230-236.
9) Müller K, Valentine-Thon E. Hypersensitivity to titanium: Clinical and laboratory evidence. Neuro Endocrinol Lett. 27(Suppl 1), 2006, pp. 31-359)