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melisa

MELISA is a blood test to aid the diagnosis of metal hypersensitivity. It is used worldwide by healthcare professionals to help determine whether patients are hypersensitive to metals commonly used in dental restorations or medical implants. Further test applications include Lyme disease.

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+44 208133 5166

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MELISA NEWSLETTER (6 per year)

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Melisa Diagnostics

2 weeks ago

We are thrilled that the US FDA is finally doing more studies on the effect of metal implants, while also admitting that animal studies do not accurately reflect what happens when metallic implants are placed in humans. In this study, they look at the potential issues with the nickel titanium (NiTi) alloy, concluding that: "the results here demonstrated that nickel and NiTi NP can enter both types of cells, with deleterious consequences." and "there are significant biocompatibility issues in metallic implants that may be missed because humans respond to nickel ions and nano-/micro-sized NiTi particles much differently than rodents".
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Examining the role of nickel and NiTi nanoparticles promoting inflammation and angiogenesis

www.tandfonline.com

Nickel titanium (NiTi, or Nitinol) alloy is used in several biomedical applications, including cardiac, peripheral vascular, and fallopian tube stents. There are significant biocompatibility issues...

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Melisa Diagnostics

4 weeks ago

Did you know that titanium dioxide - one of the most popular pigments in use - is commonly added to food, as well as to toothpaste, sunscreen and cosmetics? This year, the use of titanium dioxide (E171) as a food additive in the European Union is prohibited due to potential genotoxicity, i.e. the titanium dioxide particles’ ability to damage DNA.
A class action lawsuit has now been filed against the Mars Corporation, maker of Skittles, due to the titanium content in the sweets. In 2016, the company announced they would be eliminating titanium from their products by 2021, but so far there has been no change.
www.forbes.com/sites/ninashapiro/2022/07/17/skittles-candy-maker-sued-due-to-presence-of-additive... ... See MoreSee Less

Skittles Candy Maker Sued Due To Presence Of Additive Deemed “Toxic”

www.forbes.com

Mars Corporation, makers of Skittles, are defendants in a class action lawsuit claiming that these candies contain harmful additives.

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Melisa Diagnostics

1 month ago

Can titanium clips used in surgery cause health issues? This is a case of a 55-year-old female who after a gallbladder removal experienced pain, diarrhea, nausea and neuralgia. The patient was eventually diagnosed with a hypersensitivity reaction to the titanium clips used in the surgery. Four clips were identified and removed and the symptoms improved after removal. The patient had a known history of metal (nickel) allergy, as well as multiple other allergies. The authors recommend preoperative allergy testing for patients with history of known allergies, especially those with metal allergies to prevent further complication or aid in diagnosis and treatment.
www.cureus.com/articles/94815-hypersensitivity-reaction-post-laparoscopic-cholecystectomy-due-to-... ... See MoreSee Less

Hypersensitivity Reaction Post Laparoscopic Cholecystectomy Due to Retained Titanium Clips

www.cureus.com

Titanium is an inert metal that has many medical uses and applications because of its biocompatibility. However, titanium is not completely devoid of adverse reactions. This was the case of a 55-year-...

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Melisa Diagnostics

2 months ago

In this study, genes of patients who had developed allergies to their CoCr hip implants were compared to genes of patients who remained symptom-free. The results showed that development of delayed type hypersensitivity is associated with patient age, gender, level of metal exposure and the presence of certain genes (HLA class II alleles). The authors suggest that more resources should be directed towards improving the understanding of patients' immune responses to implant materials.
www.nature.com/articles/s43856-022-00137-0 ... See MoreSee Less

The influence of HLA genotype on the development of metal hypersensitivity following joint replacement - Communications Medicine

www.nature.com

Langton et al. identify HLA alleles associated with development of delayed-type hypersensitivity following hip arthroplasty. They train an algorithm to predict hypersensitivity which could improve imp...

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Melisa Diagnostics

2 months ago

If a patient has a known metal allergy, Dr. Pritchett recommends metal-free implant options. Also, if a patient is concerned about metal allergy or sensitivity, metal allergy tests can be done. He talks about his experience with patients with metal hypersensitivity, and what options patients have, on YouTube: www.youtube.com/watch?v=mrx9Pd8wVLo
www.seattlejointsurgeon.com/specialties/metal-free-joint-replacement ... See MoreSee Less

Metal Free Hip Replacement Dr. Pritchett

www.youtube.com

Metal Free Hip Replacement for Allergy to metal. Made with a Ceramic Coating for Adventure Sports and in Active Patients. Less invasive Surgery For A lifeti...

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