When patients with hypersensitivity to metals present for surgery where metallic prostheses are required, problems arise about the choice of the prosthesis. We present a case of a patient with proven metal sensitivity to cobalt, chromium, nickel and molybdenum, who required bilateral total knee replacement for osteoarthritis and was successfully managed by a titanium prosthesis. The patient’s MELISA test revealed a strongly positive allergy to nickel and chromium and weakly positive results for cobalt and molybdenum. Based on the MELISA report, the implant used in our patient was made from titanium, and a polyethylene insert was used to avoid the possible metal allergy. Our case demonstrated the need for proper investigation with tests such as MELISA and also the need for proper history in all such patients. Read full article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081493/