This study further explores the link between hypersensitivity to dental metals with chronic fatigue syndrome (CFS). It looks at 22 patients with autoimmune thyroiditis, 28 fatigued patients free from endocrinopathy and 22 fatigued professionals with no evidence of autoimmunity. All had their dental amalgams replaced with non-metallic materials. After six months, many patients reported disappearance of many symptoms previously encountered. Their MELISA response also fell considerably. We suggest that hypersensitivity to metal affects the hypothalamic-pituitary-adrenal axis (HPA axis) and indirectly triggers psychosomatic symptoms characterising CFS, fibromyalgia and other diseases of unknown etiology.

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